Studies on the Iron Absorption in Various Blood Diseases

Studies in Iron Absorption

P REVIOUS STUDIES showed that general systemic factors like the hemoglobin concentration, serum iron concentration, iron binding capacity, and the plasma iron clearance rate were not correlated to the intestinal iron absorption. Neither did parenteral iron treatment normalize high iron absorption.1 The purpose of the present study is to examine such local intestinal factors as the quantity and ...

Studies on Iron Absorption. Intestinal Regulatory Mechanisms.

Recent studies (1-3) have indicated that gastrointestinal absorption of iron is a more complicated process than was initially postulated (4, 5). For example, several investigators have proposed as the result of studies in rats (2, 3), dogs (6), and humans (7) that iron absorption involves at least 2 steps: 1) mucosal uptake of iron from the intestinal lumen and 2) transfer of iron from mucosal ...

[Blood protein disorders in various internal diseases].

Studies in Iron Transportation Andmetabolism . Iv . Observations on the Absorption of Iron Fromthe

Most of the problems of iron therapy which have troubled physicians during the past half century are fundamentally traceable to our ignorance of the mechanism by which iron is absorbed from the intestinal tract. Had that mechanism been understood, the discussions centering about the relative efficacy of inorganic and organic iron preparations would not have occurred, and hematologists would not...

STUDIES OF ThE PROCESS OF INTESTINAL IRON ABSORPTION IN RATS

Radioactive iron was given orally to rats which were then killed at various times in order to study the distribution of labeled iron within intestinal mucosal cells during the process of iron absorption. Rats, fasted for 16 hours, were given 100 g. of FeSO4 labeled with 5 j c. of Fe59. Periods of absorption varied from one minute to 48 hours. Segments of proximal intestine were washed and the m...